| A.P.S.R.T.C Bus Route | Bus Type | Departure | Arrival | Boarding From |
| Manthralayam - Tirupathi Via Plr | Exp | 0045 Hrs | 0345 Hrs | Manthralayam Bus Depot |  |
| Manthralayam - Tirupathi Via Mpl - Plr | Exp | 2300 Hrs | 0345 Hrs | Manthralayam Bus Depot | |
| Manthralayam - Tirupathi Via Kdr - Mpl - Plr | Exp | 2030 Hrs | 0345 Hrs | Manthralayam Bus Depot | |
| Manthralayam - Tirupathi Via Atp - Mpl - Plr | Exp | 1630 Hrs | 0345 Hrs | Manthralayam Bus Depot | |
| Manthralayam - Tirupathi Via Emgr - Adn - Atp - Mpl | Exp | 1430 Hrs | 0345 Hrs | Manthralayam Bus Depot | |
There are 5 buses in a day between Manthralayam and Tirupathi. The first bus to depart is at 0045 Hrs by A.P.S.R.T.C. This bus is Exp and the boarding point is Manthralayam Bus Depot. The journey takes 3 Hrs covering a distance of 123 Kms and the bus will reach Tirupathi at 0345 Hrs
The next bus to depart is at 2300 Hrs by A.P.S.R.T.C. This bus is Exp and the boarding point is Manthralayam Bus Depot. The journey takes 4 Hrs covering a distance of 203 Kms and the bus will reach Tirupathi at 0345 Hrs
The next bus to depart is at 2030 Hrs by A.P.S.R.T.C. This bus is Exp and the boarding point is Manthralayam Bus Depot. The journey takes 7 Hrs covering a distance of 295 Kms and the bus will reach Tirupathi at 0345 Hrs
The last bus to depart is at 1430 Hrs by A.P.S.R.T.C. This bus is Exp and the boarding point is Manthralayam Bus Depot. The journey takes 13 Hrs covering a distance of 473 Kms and the bus will reach Tirupathi at 0345 Hrs